Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner.
C. Y. Perrot, T. Karampitsakos, A. Unterman, T. Adams, K. Marlin, A. Arsenault, A. Zhao, N. Kaminski, G. Katlaps, K. Patel, D. Bandyopadhyay, J. D. Herazo-Maya
This study identifies MCEMP1 as highly expressed in monocytes and macrophages in IPF, regulated by TGFβ and involved in chemotaxis, adhesion, and migration through RHO GTPase modulation.
bioRxiv · Oct 7, 2023Immunology