Author

D. A. Hafler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Research Focus:cell type annotation· 8 Approach:statistical model· 6 Research Focus:differential expression· 5 Assay:scRNA-seq· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:cell-cell communication· 3

Frequent Co-Authors

P.-P. Axisa· 3 shared T. S. Sumida· 3 shared E. E. Longbrake· 2 shared H. A. Stillwell· 2 shared H. Asashima· 2 shared K. Raddassi· 2 shared L. E. Lucca· 2 shared L. Zhang· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

P.-P. Axisa

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Author profile →

9 papers

Recent·Most cited

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

J. Wei, J. Moon, Y. Yasumizu, L. Zhang, K. Radassi, N. Buitrago-Pocasangre, M. E. Deerhake, N. Strauli, A. Chan, A. Herman, R. Pedotti, C. Raposo, I. Yim, J. Pappalardo, E. E. Longbrake, , D. A. Hafler

This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.

bioRxiv · Feb 7, 2024 · PreprintImmunology

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

H.-J. Lee, Y. Zhao, I. Fleming, S. Mehta, X. Wang, B. Vander Wyk, S. E. Ronca, H. Kang, C.-H. Chou, B. Fatou, K. K. Smolen, O. Levy, C. B. Clish, R. J. Xavier, H. Steen, , R. R. Montgomery

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

bioRxiv · May 14, 2023Immunology

An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction

T. S. Sumida, M. R. Lincoln, L. He, Y. Park, M. Ota, H. A. Stillwell, G. A. Leissa, K. Fujio, A. Kulminski, C. B. Epstein, B. E. Bernstein, M. Kellis, D. A. Hafler

This study identifies a primate-specific PRDM1 isoform and its interaction with SGK1 as drivers of Treg dysfunction in autoimmune diseases.

bioRxiv · Dec 2, 2022 · PreprintImmunology

Neutrophils regulate ITPR2 levels in epithelia by direct injection of elastase

N. Ogino, M. F. Leite, E. Kruglov, H. Asashima, D. A. Hafler, B. E. Ehrlich, M. Nathanson

The paper shows neutrophils inject elastase into hepatocytes, reducing ITPR2 levels and calcium signals without damaging cells, and identifies a compensatory response in liver biopsies.

bioRxiv · Sep 13, 2022 · PreprintCell Biology

Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity

D. Kim, G. Biancon, Z. Bai, J. VanOudenhove, Y. Liu, S. Kothari, L. Gowda, J. M. Kwan, N. C. Buitrago-Pocasangre, N. Lele, H. Asashima, M. K. Racke, J. E. Wilson, T. S. Givens, M. M. Tomayko, , R. Fan

The paper develops a microfluidic immuno-serology assay to analyze immune responses in patients with altered immunity, finding reduced diversity in protein cooperation and impaired antibody responses in certain groups.

bioRxiv · Aug 31, 2022 · PreprintBioengineering

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells

L. E. Lucca, P.-P. Axisa, B. Lu, B. Harnett, S. Jessel, L. Zhang, K. Raddassi, L. Zhang, K. Olino, J. Clune, M. Singer, H. Kluger, D. A. Hafler

The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.

Journal of Experimental Medicine · Mar 2, 2021Peer-reviewedImmunology

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

T. S. Sumida, S. Dulberg, J. Schupp, H. A. Stillwell, P.-P. Axisa, M. Comi, M. Lincoln, A. Unterman, N. Kaminski, A. Madi, V. K. Kuchroo, D. A. Hafler

This study identifies IFN-I-regulated co-inhibitory receptor expression in human T cells through transcriptional networks and single-cell RNA-sequencing in SARS-CoV-2 infection.

bioRxiv · Oct 30, 2020Immunology

Oleic acid Induces Tissue Resident FoxP3 Regulatory T cell Lineage Stability and Suppressive Functions

S. L. Pompura, A. Wagner, A. Kitz, J. LaPerche, N. Yosef, M. Dominguez-Villar, D. A. Hafler

This study shows oleic acid enhances FoxP3 Treg stability and suppressive function through FAO-driven OXPHOS, with implications for MS pathology.

bioRxiv · Apr 14, 2020 · PreprintImmunology

Differential expression of the T cell inhibitor TIGIT in Glioblastoma and Multiple Sclerosis

L. E. Lucca, B. A. Lerner, D. DeBartolo, C. Park, G. Ponath, K. Raddassi, D. A. Hafler, D. Pitt

The paper compares TIGIT expression in glioblastoma tumor-infiltrating T cells and multiple sclerosis lesions, finding higher TIGIT expression in GBM and suggesting anti-TIGIT therapy as a potential treatment.

bioRxiv · Mar 27, 2019 · PreprintImmunology