Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
Q. Ding, Y. Wu, A. Zuchowski, E. T. Triglia, J. Gommerman, A. Subramanian, V. K. Kuchroo, D. M. Rothstein
The paper identifies TIM-4+ B cells that express proinflammatory cytokines like IL-17A and promote auto- and allo-immunity by preventing their conversion into regulatory B cells.
bioRxiv · Sep 22, 2023 · PreprintImmunology
I. Akbar, R. Tang, J. Baillargeon, A.-P. Roy, P. M. I. A. Doss, C. Zhu, V. K. Kuchroo, M. Rangachari
This study shows Serpine1 inhibits Th1 cell pathogenicity in EAE by promoting Tim-3 expression and function.
bioRxiv · Jul 13, 2023 · PreprintImmunology
P. Cadinu, K. N. Sivanathan, A. Misra, R. J. Xu, D. Mangani, E. Yang, J. M. Rone, K. Tooley, Y.-C. Kye, L. Bod, L. Geistlinger, T. Lee, N. Ono, G. Wang, L. Sanmarco, , R. Nowarski
The paper uses MERFISH to analyze gene expression in a mouse colitis model, revealing fibroblast trajectories and spatial remodeling during inflammation.
bioRxiv · May 8, 2023Immunology
L. M. Sanmarco, J. M. Rone, C. M. Polonio, F. Giovannoni, G. Fernandez Lahore, K. Ferrara, C. Gutierrez-Vazquez, N. Li, A. Sokolovska, A. Plasencia, C. Faust Akl, P. Nanda, E. S. Heck, Z. Li, H.-G. Lee, , F. J. Quintana
The paper identifies an immunometabolic pathway in dendritic cells that limits autoimmunity and develops a synthetic probiotic to activate this pathway.
bioRxiv · Mar 17, 2023 · PreprintImmunology
P. I. Thakore, A. Schnell, M. Zhao, L. Huang, Y. Hou, E. Christian, S. Zaghouani, C. Wang, V. Singh, S. Ma, V. Sankar, S. Notarbartolo, J. D. Buenrostro, F. Sallusto, N. A. Patsopoulos, , A. Regev
The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.
bioRxiv · Feb 26, 2022Immunology
M. Pawlak, D. DeTomaso, G. Meyer zu Horste, Y. Lee, J. Nyman, D. Dionne, C. Wang, A. Wallrapp, P. R. Burkett, S. J. Riesenfeld, A. C. Anderson, A. Regev, R. J. Xavier, N. Yosef, V. K. Kuchroo
This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.
bioRxiv · Jan 24, 2021 · PreprintImmunology
T. S. Sumida, S. Dulberg, J. Schupp, H. A. Stillwell, P.-P. Axisa, M. Comi, M. Lincoln, A. Unterman, N. Kaminski, A. Madi, V. K. Kuchroo, D. A. Hafler
This study identifies IFN-I-regulated co-inhibitory receptor expression in human T cells through transcriptional networks and single-cell RNA-sequencing in SARS-CoV-2 infection.
bioRxiv · Oct 30, 2020Immunology
A. Gandhi, Z.-Y. J. SUN, W. M. KIM, Y.-H. Huang, Y. Kondo, D. A. Bonsor, E. J. Sundberg, G. Wagner, V. K. Kuchroo, G. A. Petsko, R. S. Blumberg
This study identifies key residues and structural dynamics governing the monomer-dimer equilibrium of hCEACAM1 using biophysical and structural methods.
bioRxiv · Jul 14, 2020Immunology
D. J. Puleston, F. Baixauli, D. E. Sanin, M. Villa, A. Kabat, M. M. Kaminski, H. Weiss, K. Grzes, L. J. Flachsmann, C. S. Field, M. Stanckzak, L. Schimmelpfennig, F. Hassler, C. Wang, N. Yosef, , E. L. Pearce
This study shows that polyamine metabolism, specifically through hypusination, is essential for maintaining T cell subset identity by regulating the epigenome and transcriptional programs.
bioRxiv · Jan 24, 2020 · PreprintImmunology
N. Acharya, A. Madi, H. Zhang, M. Klapholz, E. Christian, K. O. Dixon, G. Fell, K. Tooley, D. Mangani, J. Xia, M. Singer, D. Neuberg, O. Rozenblatt-Rosen, A. Regev, V. K. Kuchroo, A. C. Anderson
This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.
bioRxiv · Oct 10, 2019 · PreprintImmunology
N. Y. Lai, M. A. Musser, F. A. Pinho-Ribeiro, P. Baral, P. Ma, D. E. Potts, Z. Chen, D. Paik, S. Soualhi, H. Shi, A. Misra, K. Goldstein, K. N. Sivanathan, A. Jacobson, A. Wallrapp, , I. M. Chiu
This study shows gut-innervating nociceptors protect against Salmonella typhimurium infection by modulating microbiota and Peyer’s patch microfold cells.
bioRxiv · Mar 21, 2019 · PreprintImmunology