Author

P.-P. Axisa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

D. A. Hafler· 3 shared L. E. Lucca· 2 shared L. Zhang· 2 shared T. S. Sumida· 2 shared A. Chan· 1 shared A. Herman· 1 shared A. Madi· 1 shared A. Perrot· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

D. A. Hafler

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4 papers

Recent·Most cited

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

J. Wei, J. Moon, Y. Yasumizu, L. Zhang, K. Radassi, N. Buitrago-Pocasangre, M. E. Deerhake, N. Strauli, A. Chan, A. Herman, R. Pedotti, C. Raposo, I. Yim, J. Pappalardo, E. E. Longbrake, , D. A. Hafler

This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.

bioRxiv · Feb 7, 2024 · PreprintImmunology

Inflamed Natural Killer cells with adhesion defects are associated with a poor prognosis in Multiple Myeloma

E. Blanquart, R. Ekren, B. Rigaud, M.-V. Joubert, V. Baylot, H. Daunes, M. Cuisinier, M. Villard, N. Carrie, C. Mazzotti, L. E. Lucca, A. Perrot, J. Corre, T. Walzer, H. Avet-Loiseau, , L. Martinet

This study identifies CD16/CD226low NK cells with inflammatory signatures and reduced effector functions in multiple myeloma patients, correlating with poor clinical outcomes.

bioRxiv · Jan 15, 2024 · PreprintImmunology

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells

L. E. Lucca, P.-P. Axisa, B. Lu, B. Harnett, S. Jessel, L. Zhang, K. Raddassi, L. Zhang, K. Olino, J. Clune, M. Singer, H. Kluger, D. A. Hafler

The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.

Journal of Experimental Medicine · Mar 2, 2021Peer-reviewedImmunology

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

T. S. Sumida, S. Dulberg, J. Schupp, H. A. Stillwell, P.-P. Axisa, M. Comi, M. Lincoln, A. Unterman, N. Kaminski, A. Madi, V. K. Kuchroo, D. A. Hafler

This study identifies IFN-I-regulated co-inhibitory receptor expression in human T cells through transcriptional networks and single-cell RNA-sequencing in SARS-CoV-2 infection.

bioRxiv · Oct 30, 2020Immunology