A. Madi

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.

Pan-cancer mapping of single T cell profiles reveals a TCF1:CXCR6-CXCL16 regulatory axis essential for effective anti-tumor immunity

The paper identifies a TCF1:CXCR6-CXCL16 regulatory axis critical for anti-tumor immunity by analyzing single-cell RNA-seq data from multiple cancers.

Antigen experience relaxes the organisational structure of the T cell receptor repertoire

The paper examines how antigen exposure affects the structural organization of T cell receptor repertoires in mice across different life stages and infection states.

Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage

This study finds frequent aneuploidy and chromosomal truncations in CRISPR-Cas9-edited primary human T cells, associated with reduced proliferation and p53 activation.

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

This study identifies IFN-I-regulated co-inhibitory receptor expression in human T cells through transcriptional networks and single-cell RNA-sequencing in SARS-CoV-2 infection.

Transient cell-in-cell formation underlies tumor resistance to immunotherapy

This study identifies transient cell-in-cell formations as a mechanism enabling tumor resistance to immunotherapy, showing they protect tumor cells from immune and chemotherapy attacks.

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity

This study shows lung fibroblasts in breast cancer metastases are transcriptionally dynamic and plastic, with stage-specific gene signatures and Myc as a key regulator linked to poor survival.

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.