A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19
M. de Vries, A. Mohamed, R. A. Prescott, A. Valero-Jimenez, L. Desvignes, R. O'Connor, C. Steppan, J. C. Devlin, E. Ivanova, A. Herrera, A. Schinlever, P. Loose, K. Ruggles, S. Koralov, A. Anderson, , M. Dittmann
This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.
bioRxiv · Aug 28, 2020 · PreprintMicrobiology