M. de Vries

E-cigarette vapour induces cellular senescence in primary lung fibroblasts and may contribute to lung pathology

This study shows E-cigarette vapour induces cellular senescence in primary human lung fibroblasts, impairing tissue repair, but not in a mouse model.

A comparative study of in vitro air-liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolution

This study compares gene expression and cellular heterogeneity in HAE cultures derived from BCi-NS1.1 cell lines and primary cells using scRNA-Seq, finding similar morphology and transcriptional patterns but some interferon gene differences.

In-silico docking platform with serine protease inhibitor (SERPIN) structures identifies host cysteine protease targets with significance for SARS-CoV-2

The paper uses in-silico docking to identify SERPIN targets in SARS-CoV-2, finding novel interactions and validating their role in viral replication.

ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection

The paper identifies ACE2-containing exosomes, termed defensosomes, that inhibit SARS-CoV-2 infection by binding and blocking viral entry.

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

LY-CoV555, an anti-spike antibody from a convalescent COVID-19 patient, neutralizes SARS-CoV-2 and protects non-human primates against infection.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

High titers of multiple antibody isotypes against the SARS-CoV-2 spike receptor-binding domain and nucleoprotein associate with better neutralization.

The paper assesses neutralization capacity and antibody titers against SARS-CoV-2 antigens in recovered healthcare workers, finding that high titers of multiple isotypes correlate with neutralization.

Soil salinity inhibits plant shade avoidance

This study shows that soil salinity inhibits plant shade avoidance by interfering with ABA and BR signaling pathways, suppressing PIF function.

The regulatory factor ELF1 triggers a critical wave of transcription in the antiviral response to type I interferon

This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.

A stress recovery signaling network for enhanced flooding tolerance in Arabidopsis thaliana

This paper identifies a signaling network in Arabidopsis thaliana that enhances flooding tolerance by regulating ROS homeostasis, stomatal aperture, and chlorophyll degradation during recovery.

Arabidopsis JASMONATE-INDUCED OXYGENASES down-regulate plant immunity by hydroxylation and inactivation of the hormone jasmonic acid

This paper identifies four JOX enzymes in Arabidopsis that hydroxylate jasmonic acid (JA) to inactivate it, thereby down-regulating JA-dependent defenses and balancing growth-defense tradeoffs.

Architecture and dynamics of the jasmonic acid gene regulatory network

This study uses RNA-Seq time series analysis of Arabidopsis thaliana to detail the dynamics of the jasmonic acid gene regulatory network and identify key transcription factors involved in plant defense.