Author

L. Desvignes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Dittmann· 3 shared A. Schinlever· 2 shared B. A. Rodriguez-Rodriguez· 2 shared M. de Vries· 2 shared A. Anderson· 1 shared A. Bazley· 1 shared A. Cornelius· 1 shared A. Herrera· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

M. Dittmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

B. A. Rodriguez-Rodriguez, G. Ciabattoni, R. Duerr, A. M. Valero-Jimenez, S. T. Yeung, K. M. Crosse, A. Schinlever, L. Bernard-Raichon, J. J. Rodriguez-Galvan, M. McGrath, S. Vashee, Y. Xue, C. Loomis, K. M. Khanna, K. H. Cadwell, , M. Dittmann

This study establishes a neonatal mouse model to study SARS-CoV-2 transmissibility, showing variant differences in infectious shedding and identifying ORF8's role in transmission.

bioRxiv · Oct 4, 2022 · PreprintMicrobiology

Bacterial strain-dependent dissociation of cell recruitment and cell-to-cell spread in early M. tuberculosis infection

B. S. Zha, L. Desvignes, T. Fergus, A. Cornelius, T.-Y. Cheng, D. B. Moody, J. D. Ernst

This study compares early infection dynamics of two M. tuberculosis strains, showing strain-specific differences in bacterial spread and immune activation.

bioRxiv · May 10, 2022Immunology

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

M. de Vries, A. Mohamed, R. A. Prescott, A. Valero-Jimenez, L. Desvignes, R. O'Connor, C. Steppan, J. C. Devlin, E. Ivanova, A. Herrera, A. Schinlever, P. Loose, K. Ruggles, S. Koralov, A. Anderson, , M. Dittmann

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

High titers of multiple antibody isotypes against the SARS-CoV-2 spike receptor-binding domain and nucleoprotein associate with better neutralization.

M. G. Noval, M. E. Kaczmarek, A. Koide, B. A. Rodriguez-Rodriguez, P. Louie, T. Tada, T. Hattori, T. Panchenko, L. A. Romero, K. W. Teng, A. Bazley, M. de Vries, M. I. Samanovic, J. N. Weiser, I. Aifantis, , K. A. Stapleford

The paper assesses neutralization capacity and antibody titers against SARS-CoV-2 antigens in recovered healthcare workers, finding that high titers of multiple isotypes correlate with neutralization.

bioRxiv · Aug 15, 2020 · PreprintMicrobiology