Author

A. W. C. Yan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

J. C. Brown· 2 shared K. Sukhova· 2 shared T. P. Peacock· 2 shared W. S. Barclay· 2 shared A. H. Patel· 1 shared C. M. Donato· 1 shared C. P. McCormack· 1 shared D. Bailey· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMicrobiology

J. C. Brown

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modelling the viral dynamics of the SARS-CoV-2 Delta and Omicron variants in different cell types

C. P. McCormack, A. W. C. Yan, J. C. Brown, K. Sukhova, T. P. Peacock, W. S. Barclay, I. Dorigatti

This study models SARS-CoV-2 Delta and Omicron replication in nasal and lung cells, finding Omicron has higher infectivity but lower production rate than Delta, leading to higher transmission in nasal cells and higher severity in lung cells.

bioRxiv · Mar 15, 2023 · PreprintMicrobiology

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

T. P. Peacock, J. C. Brown, J. Zhou, N. Thakur, K. Sukhova, J. Newman, R. Kugathasan, A. W. C. Yan, W. Furnon, G. De Lorenzo, V. M. Cowton, D. Reuss, M. Moshe, O. K. Platt, J. L. Quantrill, , W. S. Barclay

This study identifies distinct genetic determinants in the Omicron spike protein for altered cell entry and antigenic properties, showing they are separable and may affect future variant severity and vaccine efficacy.

bioRxiv · Dec 31, 2021 · PreprintMicrobiology

Saturation of influenza virus neutralization and antibody consumption can both lead to bistable growth kinetics

S. Xu, A. W. C. Yan, H. Peck, L. Gillespie, I. G. Barr, X. Yang, S. J. Turner, C. M. Donato, T. Zhang, M. Olshansky, V. Dhanasekaran

The paper uses mathematical models and focus reduction assays to show that influenza virus neutralization and antibody consumption can lead to bistable growth kinetics, explaining reinfection and vaccine efficacy.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology