Author

S. J. Turner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3

Frequent Co-Authors

M. Olshansky· 4 shared J. Li· 3 shared A. Barugahare· 2 shared B. E. Russ· 2 shared J. E. Prier· 2 shared A. Achour· 1 shared A. Cardus Figueras· 1 shared A. D. Duru· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersImmunology

M. Olshansky

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

B. E. Russ, K. Tsyganov, S. Quon, B. Yu, J. Li, J. K. Lee, M. Olshansky, Z. He, P. F. Harrison, A. Barugahare, M. See, S. Nuessing, A. E. Morey, V. A. Udupa, T. J. Bennett, , S. J. Turner

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

bioRxiv · Feb 26, 2023 · PreprintImmunology

Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements

D. Millrine, A. Cardus Figueras, J. Uceda Fernandez, R. Andrews, B. Szomolay, B. C. Cossins, C. Rice, J. Li, V. Tyrrell, L. mcLeod, P. Holmans, V. O'Donnell, P. Taylor, S. J. Turner, B. J. Jenkins, , S. A. Jones

The paper investigates how IFN-gamma-secreting CD4+ T-cells alter the transcriptional output of IL-6 by redirecting STAT1 and STAT3 to Alu-like retroelements during inflammation.

bioRxiv · Jul 18, 2022 · PreprintImmunology

Saturation of influenza virus neutralization and antibody consumption can both lead to bistable growth kinetics

S. Xu, A. W. C. Yan, H. Peck, L. Gillespie, I. G. Barr, X. Yang, S. J. Turner, C. M. Donato, T. Zhang, M. Olshansky, V. Dhanasekaran

The paper uses mathematical models and focus reduction assays to show that influenza virus neutralization and antibody consumption can lead to bistable growth kinetics, explaining reinfection and vaccine efficacy.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation.

J. Li, K. Hardy, M. Olshansky, A. Barugahare, L. J. Gearing, J. E. Prier, X. Y. Sng, M. L. T. Nguyen, D. Piovesan, B. E. Russ, N. L. La Gruta, P. Hertzog, S. Rao, S. J. Turner

This study identifies KDM6B-dependent chromatin remodelling as critical for virus-specific CD8+ T cell differentiation and memory formation.

bioRxiv · Feb 3, 2020 · PreprintImmunology

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

A. Achour, A. D. Duru, R. Sun, E. B. Allerbring, J. Chadderton, N. Kadri, X. Han, H. Uchtenhagen, C. Madhurantakam, S. Pellegrino, T. Sandalova, P.-A. Nygren, S. J. Turner

This paper shows that modifying peptides with proline can restore CD8 T-cell recognition of viral escape variants, enhancing vaccine effectiveness against immune evasion.

bioRxiv · Dec 2, 2019Immunology

Development of a KDM6b shRNA conditional knock down mouse model

J. E. Prier, M. E. Blewitt, R. A. Dickins, S. J. Turner

This paper develops a conditional KDM6b shRNA mouse model and shows that its knockdown reduces CD8+ T cell responses to influenza A infection without affecting T-BET expression.

bioRxiv · Apr 11, 2019 · PreprintImmunology

Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionality

T. S. C. Hinks, E. Marchi, M. Jabeen, M. Olshansky, A. Kurioka, T. J. Pediongco, B. S. Meehan, L. Kostenko, S. J. Turner, A. J. Corbett, Z. Chen, P. Klenerman, J. McCluskey

The paper defines the transcriptome of activated MAIT cells in mice and humans and shows how it changes during infection phases, revealing a tissue repair phenotype.

bioRxiv · Dec 9, 2018 · PreprintImmunology