Author

A. W. Guiguemde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Assay:metabolomics· 1 Organism:plant (other)· 1 Approach:statistical model· 1

Frequent Co-Authors

A. P. Waters· 1 shared B. Taft· 1 shared C. Regnault· 1 shared E. Martin· 1 shared F. Nigsch· 1 shared F. Yokokawa· 1 shared J. Straimer· 1 shared M. P. Barrett· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. P. Waters

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A conserved metabolic signature associated with response to fast-acting antimalarial agents

N. V. Simwela, A. W. Guiguemde, J. Straimer, C. Regnault, F. Yokokawa, B. Taft, T. T. Diagana, M. P. Barrett, A. P. Waters

This paper identifies a conserved metabolic signature in malaria parasites exposed to fast-acting antimalarial drugs, suggesting a common mechanism of action.

bioRxiv · Oct 3, 2022 · PreprintMicrobiology

De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

M. Pikusa, O. Rene, S. Williams, Y.-L. Chen, E. Martin, W. J. Godinez, S. P. S. Rao, A. W. Guiguemde, F. Nigsch

This paper uses AI-driven generative chemistry to design a novel molecule active against Chagas disease parasites, validated experimentally.

bioRxiv · Dec 10, 2021 · PreprintPharmacology & Toxicology