BiochemistrybioRxiv
Recruitment of FBXO22 for Targeted Degradation of NSD2
D. Y. Nie, J. R. Tabor, J. Li…·C. Arrowsmith
This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.
DOI 10.1038/s41589-024-01660-y