Y. Sasaki

Glutathione supersulphide regulates T-cell receptor signalling

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.

Classification of Extracellular Vesicles based on Surface Glycan Structures by Spongy-like Separation Media

This paper introduces a novel lectin-based affinity chromatography method using spongy monoliths to classify extracellular vesicles based on surface glycan structures and demonstrates subpopulations through proteome profiling.

Canonical Strigolactones Are Not the Tillering-Inhibitory Hormone but Rhizospheric Signals in Rice

This study shows canonical strigolactones in rice are not responsible for shoot branching inhibition but act as rhizospheric signals to influence Striga germination and mycorrhizal colonization.

A chemical strategy toward novel brain-penetrant EZH2 inhibitors

This paper identifies a chemical strategy to develop brain-penetrant EZH2 inhibitors and reports two novel compounds with improved properties.

Genome-scale metabolic rewiring to achieve predictable titers rates and yield of a non-native product at scale

This study engineers Pseudomonas putida to produce indigoidine with high titer, rate, and yield by coupling product formation with growth through metabolic rewiring and CRISPRi knockdowns.