Author

D. D. Owens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

D. Barsyte-Lovejoy· 2 shared M. Szewczyk· 2 shared A. J. Lamberto· 1 shared A. M. Barsotti· 1 shared A. Pon· 1 shared A. Scheremetjew· 1 shared A. W. Stamford· 1 shared B. Mirabi· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

D. Barsyte-Lovejoy

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Author profile →

2 papers

Recent·Most cited

Recruitment of FBXO22 for Targeted Degradation of NSD2

D. Y. Nie, J. R. Tabor, J. Li, M. Kutera, J. St-Germain, R. P. Hanley, E. Z. WOLF, E. Paulakonis, T. M. G. Kenney, S. Duan, S. Shrestha, D. D. Owens, A. Pon, M. Szewczyk, A. J. Lamberto, , C. Arrowsmith

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

bioRxiv · Nov 1, 2023Biochemistry

Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6

R. J. Harding, I. Franzoni, M. K. Mann, M. Szewczyk, B. Mirabi, D. D. Owens, S. Ackloo, A. Scheremetjew, K. A. Juarez-Ornelas, R. Sanichar, R. J. Baker, C. Dank, P. J. Brown, D. Barsyte-Lovejoy, V. Santhakumar, , C. H. Arrowsmith

The paper identifies and characterizes a chemical probe, SGC-UBD253, that targets the HDAC6 UBD with selectivity, and a less active derivative as a negative control.

bioRxiv · Feb 21, 2023Pharmacology & Toxicology