TRPV1 activation relies on hydration/dehydration of nonpolar cavities
M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale
The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.
bioRxiv · May 5, 2017Biophysics