Author

T. Rohacs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:mechanistic / dynamical model· 4 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

V. Carnevale· 4 shared M. A. Kasimova· 3 shared S. Zhao· 3 shared Y. Yudin· 3 shared A. Samanta· 2 shared A. T. Yazici· 2 shared E. Gianti· 2 shared K. W. Huynh· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiophysics

V. Carnevale

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Author profile →

7 papers

Recent·Most cited

Computational and functional characterization of the PI(4,5)P2 binding site of the TRPM3 ion channel

S. Zhao, V. Carnevale, E. Gianti, T. Rohacs

This study identifies PI(4,5)P2 binding residues in TRPM3 and shows their role in channel regulation and interactions with ligands and G{beta}{gamma}.

bioRxiv · Jun 5, 2022 · PreprintBiophysics

A Piezo1 open state reveals a multi-fenestrated ion permeation pathway

W. Jiang, J. S. Del Rosario, W. M. Botello-Smith, S. Zhao, Y.-C. Lin, H. Zhang, J. J. Lacroix, T. Rohacs, Y. L. Luo

The paper uses molecular dynamics simulations to study Piezo1 channel opening and identifies a multi-fenestrated ion permeation pathway.

Communications Biology · Jan 19, 2021Peer-reviewedBiophysics

Molecular mechanism of TRPV2 channel modulation by cannabidiol

R. A. Pumroy, A. Samanta, Y. Liu, T. E. T. Hughes, S. Zhao, Y. Yudin, K. W. Huynh, Z. H. Zhou, T. Rohacs, S. Han, V. Y. Moiseenkova-Bell

This study determines the structure of TRPV2 bound to cannabidiol, revealing a unique binding site and the role of the S4-S5 linker in channel gating.

bioRxiv · May 24, 2019Biophysics

Phosphoinositides regulate the TRPV1 channel via two functionally distinct binding sites

A. T. Yazici, E. Gianti, M. A. Kasimova, V. Carnevale, T. Rohacs

This study resolves a controversy about TRPV1 regulation by showing phosphoinositides act through two distinct binding sites, one inhibitory and one activating.

bioRxiv · Feb 22, 2019 · PreprintBiophysics

The G protein-biased PZM21 and TRV130 act as partial agonists of μ-opioid receptors signaling to ion channel targets

Y. Yudin, T. Rohacs

This study compares the effects of G protein-biased opioid agonists TRV130, PZM21, and herkinorin with the full agonist DAMGO on ion channel targets, finding reduced activation of GIRK2 and inhibition of TRPM3 and CaV2.2 channels.

bioRxiv · Oct 17, 2018Pharmacology & Toxicology

Structural insights on TRPV5 gating by endogenous modulators

T. E. T. Hughes, R. A. Pumroy, A. T. Yazici, M. A. Kasimova, E. C. Fluck, K. W. Huynh, A. Samanta, S. Molugu, Z. H. Zhou, V. Carnevale, T. Rohacs, V. Y. Moiseenkova-Bell

The paper determines TRPV5 structures with endogenous modulators PI(4,5)P2 and CaM, revealing their mechanisms of activation and inhibition.

bioRxiv · Jul 31, 2018Biophysics

TRPV1 activation relies on hydration/dehydration of nonpolar cavities

M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.

bioRxiv · May 5, 2017Biophysics