Author

D. Granata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

V. Carnevale· 3 shared A. Yazici· 2 shared M. L. Klein· 2 shared T. Rohacs· 2 shared Y. Yudin· 2 shared A. T. Nielsen· 1 shared C. K. Colenso· 1 shared D. Cabezas-Bratesco· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

V. Carnevale

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Author profile →

4 papers

Recent·Most cited

Sequence conservation and structural features that are common within TRP channels

D. Cabezas-Bratesco, C. K. Colenso, K. Zavala, D. Granata, V. Carnevale, J. C. Opazo, S. E. Brauchi

The paper identifies a conserved residue fingerprint in TRP channels that may explain differences in coupling strategies among subgroups.

bioRxiv · Sep 6, 2021Evolutionary Biology

Synergistic stabilization of a double mutant in CI2 from an in-cell library screen

L. Hamborg, D. Granata, J. G. Olsen, J. V. Roche, L. E. Pedersen, A. T. Nielsen, K. Lindorff-Larsen, K. Teilum

The paper identifies two stabilizing variants of barley chymotrypsin inhibitor 2, showing synergistic effects in a double mutant.

bioRxiv · Dec 1, 2020Biophysics

A consistent picture of TRPV1 activation emerges from molecular simulations and experiments

M. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper proposes a molecular mechanism for TRPV1 activation through conformational changes and validates it with bioinformatics, structural analysis, and experimental data.

bioRxiv · Aug 24, 2018 · PreprintBiophysics

TRPV1 activation relies on hydration/dehydration of nonpolar cavities

M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.

bioRxiv · May 5, 2017Biophysics