Author

Y. Yudin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

T. Rohacs· 3 shared A. Samanta· 1 shared A. Yazici· 1 shared D. Granata· 1 shared K. W. Huynh· 1 shared M. A. Kasimova· 1 shared M. L. Klein· 1 shared R. A. Pumroy· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

T. Rohacs

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3 papers

Recent·Most cited

Molecular mechanism of TRPV2 channel modulation by cannabidiol

R. A. Pumroy, A. Samanta, Y. Liu, T. E. T. Hughes, S. Zhao, Y. Yudin, K. W. Huynh, Z. H. Zhou, T. Rohacs, S. Han, V. Y. Moiseenkova-Bell

This study determines the structure of TRPV2 bound to cannabidiol, revealing a unique binding site and the role of the S4-S5 linker in channel gating.

bioRxiv · May 24, 2019Biophysics

The G protein-biased PZM21 and TRV130 act as partial agonists of μ-opioid receptors signaling to ion channel targets

Y. Yudin, T. Rohacs

This study compares the effects of G protein-biased opioid agonists TRV130, PZM21, and herkinorin with the full agonist DAMGO on ion channel targets, finding reduced activation of GIRK2 and inhibition of TRPM3 and CaV2.2 channels.

bioRxiv · Oct 17, 2018Pharmacology & Toxicology

TRPV1 activation relies on hydration/dehydration of nonpolar cavities

M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.

bioRxiv · May 5, 2017Biophysics