Author

A.-S. Krebs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. Howe· 4 shared P. Zhang· 4 shared L. Mendonca· 3 shared J. Radecke· 2 shared S. Morris· 2 shared T. Lambe· 2 shared T. Ni· 2 shared Y. Sheng· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersMicrobiology

A. Howe

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4 papers

Recent·Most cited

Molecular architecture and conservation of an immature human endogenous retrovirus

A.-S. Krebs, H.-F. Liu, Y. Zhou, J. S. Rey, L. Levintov, J. Shen, A. Howe, J. R. Perilla, A. Bartesaghi, P. Zhang

The paper determines the structure of immature HERV-K VLPs using cryoET STA, revealing conserved assembly mechanisms across retroviruses.

bioRxiv · Jun 7, 2023Microbiology

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

P. Zhang, S. Gilbert, J. Radecke, T. Ni, L. Mendonca, Y. Zhu, A. Howe, P. M. Shah, Y. Sheng, A.-S. Krebs, H. M. E. Duyvesteyn, E. Allen, T. Lambe, C. Bissett, S. Morris, , D. I. Stuart

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

bioRxiv · May 22, 2023Microbiology

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

Y. Watanabe, L. Mendonca, E. R. Allen, A. Howe, M. Lee, J. D. Allen, H. Chawla, D. Pulido, F. Donnellan, H. Davies, M. Ulaszewska, S. Belij-Rammerstorfer, S. Morris, A.-S. Krebs, W. Dejnirattisai, , M. Crispin

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

bioRxiv · Jan 15, 2021Microbiology

SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

L. Mendonca, A. Howe, J. B. Gilchrist, D. Sun, M. Knight, L. C. Zanetti-Domingues, B. Bateman, A.-S. Krebs, L. Chen, J. Radecke, Y. Sheng, V. D. Li, T. Ni, I. Kounatidis, M. A. Koronfel, , P. Zhang

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

bioRxiv · Nov 5, 2020 · PreprintMicrobiology