Author

T. Lambe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Immunology· 7 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 18 Research Focus:host-pathogen & immune response· 15 Organism:mouse· 8 Organism:human· 6 Research Focus:cell type annotation· 4 Organism:rat· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

S. C. Gilbert· 11 shared M. Ulaszewska· 6 shared N. van Doremalen· 6 shared S. Belij-rammerstorfer· 6 shared G. Saturday· 5 shared S. Gilbert· 5 shared V. Munster· 5 shared A. J. Spencer· 4 shared

Activity by Year

2019-2023 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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11 shared papersMicrobiology

S. C. Gilbert

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Author profile →

18 papers

Recent·Most cited

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses

A. Flaxman, S. Sebastian, S. Appelberg, K. Cha, M. Ulaszewska, J. Purushotham, C. Gilbride, H. Sharpe, A. Spencer, S. Bibi, D. Wright, S. Dowall, L. Easterbrook, S. Findlay-Wilson, S. Gilbert, , T. Lambe

This paper develops a multi-pathogen vaccine targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses, showing strong immunogenicity and protective efficacy in animal models.

bioRxiv · Nov 3, 2023 · PreprintImmunology

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

P. Zhang, S. Gilbert, J. Radecke, T. Ni, L. Mendonca, Y. Zhu, A. Howe, P. M. Shah, Y. Sheng, A.-S. Krebs, H. M. E. Duyvesteyn, E. Allen, T. Lambe, C. Bissett, S. Morris, , D. I. Stuart

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

bioRxiv · May 22, 2023Microbiology

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

E. Mitsi, M. O. Diniz, J. Reine, A. M. Collins, R. Robinson, A. Hyder-Wright, M. Farrar, K. Liatsikos, J. Hamilton, O. Onyema, B. C. Urban, C. Solorzano, T. Lambe, S. J. Draper, D. Weiskopf, , D. M. Ferreira

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

bioRxiv · Jan 25, 2023 · PreprintImmunology

Infection- or vaccine mediated immunity reduces SARS-CoV-2 transmission, but increases competitiveness of Omicron in hamsters

J. R. Port, C. K. Yinda, J. C. Riopelle, Z. A. Weishampel, T. A. Saturday, V. A. Avanzato, J. E. Schukz, M. G. Holbrook, K. Barbian, R. Perry-Gottschalk, E. Haddock, C. Martens, C. I. Shaia, T. Lambe, S. C. Gilbert, , V. J. Munster

This study shows that vaccination and prior infection reduce SARS-CoV-2 transmission but increase Omicron competitiveness in hamsters compared to Delta.

bioRxiv · Jul 29, 2022 · PreprintMicrobiology

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

A. Tuekprakhon, J. Huo, R. Nutalai, A. Dijokaite-Guraliuc, D. Zhou, H. M. Ginn, M. Sekvaraj, C. Liu, A. J. Mentzer, P. Supasa, H. M. E. Duyvesteyn, R. Das, D. Skelly, T. G. Ritter, A. Amini, , G. R. Screaton

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

bioRxiv · May 21, 2022 · PreprintMicrobiology

ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys

N. van Doremalen, V. Avanzato, F. Feldmann, J. Schulz, E. Haddock, A. Okumura, J. Lovaglio, P. Hanley, K. Cordova, G. Saturday, T. Lambe, S. C. Gilbert, V. Munster

ChAdOx1 NiV vaccination protects African green monkeys from lethal Nipah virus infection, preventing disease signs and viral replication.

bioRxiv · Jul 20, 2021Microbiology

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

A. J. Spencer, S. Morris, M. Ulaszewska, C. Powers, R. Kaliath, C. D. Bissett, A. Truby, N. Thakur, J. Newman, E. R. Allen, I. Rudiansyah, C. Lui, W. Dejnirattisai, J. Mongkolsapaya, H. Davies, , T. Lambe

bioRxiv · Jun 8, 2021Immunology

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2

W. - Dejnirattisai, D. - Zhou, P. - Supasa, C. - Liu, A. J. Mentzer, H. M. Ginn, Y. - Zhao, H. M. E. Duyvesteyn, A. Tuekprakhon, R. Nutalai, B. - Wang, G. C. Paesen, C. - Lopez-Camacho, J. - Slon-Campos, T. Walter, , Barne

This study compares antibody resistance of SARS-CoV-2 variants P.1, B.1.351, and B.1.1.7, finding P.1 is less resistant to antibodies despite similar ACE2 binding mutations.

bioRxiv · Mar 12, 2021Microbiology

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

R. Fischer, N. van Doremalen, D. Adney, C. Yinda, J. Port, M. Holbrook, J. Schulz, B. Williamson, T. Thomas, K. Barbian, S. Anzick, S. Ricklefs, B. Smith, D. Long, C. Martens, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

bioRxiv · Mar 11, 2021Microbiology

Heterologous vaccination regimens with self-amplifying RNA and Adenoviral COVID vaccines induce robust immune responses in mice

A. J. Spencer, P. F. McKay, S. Belij-Rammerstorfer, M. Ulaszewska, C. D. Bissett, K. Hu, K. Samnuan, A. K. Blakney, H. R. Sharpe, D. Wright, C. Gilbride, A. Truby, E. R. Allen, S. C. Gilbert, R. J. Shattock, T. Lambe

This study shows that heterologous vaccination with self-amplifying RNA and adenoviral SARS-CoV-2 vaccines in mice produces stronger antibody and cellular immune responses than single-dose regimens.

bioRxiv · Jan 28, 2021Immunology

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

Y. Watanabe, L. Mendonca, E. R. Allen, A. Howe, M. Lee, J. D. Allen, H. Chawla, D. Pulido, F. Donnellan, H. Davies, M. Ulaszewska, S. Belij-Rammerstorfer, S. Morris, A.-S. Krebs, W. Dejnirattisai, , M. Crispin

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

bioRxiv · Jan 15, 2021Microbiology

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

N. van Doremalen, J. Purushotham, J. Schulz, M. Holbrook, T. Bushmaker, A. Carmody, J. Port, K. C. Yinda, A. Okumura, G. Saturday, F. Amanat, F. Krammer, P. Hanley, B. Smith, J. Lovaglio, , V. Munster

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

bioRxiv · Jan 9, 2021 · PreprintMicrobiology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

A. Silva-Cayetano, W. S. Foster, S. Innocentin, S. Belij-Rammerstorfer, A. J. Spencer, O. T. Burton, S. Fra-Bido, J. L. Lee, N. Thakur, C. Conceicao, D. Wright, J. Barrett, N. Evans-Bailey, C. Noble, D. Bailey, , M. A. Linterman

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

bioRxiv · Oct 27, 2020Immunology

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

S. P. Graham, R. K. McLean, A. J. Spencer, S. Belij-Rammerstorfer, D. Wright, M. Ulaszewska, J. C. Edwards, J. W. P. Hayes, V. Martini, N. Thakur, C. Conceicao, I. Dietrich, H. Shelton, R. Waters, A. Ludi, , T. Lambe

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

bioRxiv · Jun 20, 2020Immunology

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

N. van Doremalen, T. Lambe, A. Spencer, S. Belij-Rammerstorfer, J. Purushotham, J. Port, V. Avanzato, T. Bushmaker, A. Flaxman, M. Ulaszewska, F. Feldmann, E. Allen, H. Sharpe, J. Schulz, M. Holbrook, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

bioRxiv · May 13, 2020 · PreprintMicrobiology

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

N. van Doremalen, E. Haddock, F. Feldmann, K. Meade-White, T. Bushmaker, R. Fischer, A. Okumura, P. Hanley, G. Saturday, N. Edwards, M. Clark, T. Lambe, S. Gilbert, V. Munster

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

bioRxiv · Apr 13, 2020 · PreprintMicrobiology

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells

E. Brenna, A. N. Davydov, K. Ladell, J. E. McLaren, P. Bonaiuti, M. Metsger, S. C. Gilbert, T. Lambe, D. A. Price, S. L. Campion, D. M. Chudakov, P. Borrow, A. J. McMichael

The paper examines clonal relationships between Tfh cells in blood and tonsil, finding clonal convergence between peripheral and tonsillar Tfh cells but divergence from non-Tfh CD4+ cells.

bioRxiv · Aug 22, 2019Immunology