Author

T. Ni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Biophysics· 2 Biochemistry· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Assay:cryo-EM· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Approach:microscopy & imaging analysis· 4 Organism:human· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

P. Zhang· 6 shared J. Radecke· 3 shared L.-N. Liu· 3 shared X. Yu· 3 shared Y. Zhu· 3 shared A. Howe· 2 shared A.-S. Krebs· 2 shared L. Mendonca· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

P. Zhang

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

T. Ni, Q. Jiang, P. C. Ng, J. Shen, H. Dou, Y. Zhu, J. Radecke, G. F. Dykes, F. Huang, L.-N. Liu, P. Zhang

The paper investigates the role of intrinsically disordered CsoS2 in α-carboxysome shell assembly using synthetic engineering and cryoEM structures, revealing its function as a molecular thread and identifying a conserved interaction motif.

bioRxiv · Jun 24, 2023Microbiology

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

P. Zhang, S. Gilbert, J. Radecke, T. Ni, L. Mendonca, Y. Zhu, A. Howe, P. M. Shah, Y. Sheng, A.-S. Krebs, H. M. E. Duyvesteyn, E. Allen, T. Lambe, C. Bissett, S. Morris, , D. I. Stuart

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

bioRxiv · May 22, 2023Microbiology

Structures of perforin-2 in solution and on a membrane reveal mechanisms for pore formation

X. Yu, T. Ni, G. Munson, P. Zhang, R. J. C. Gilbert

This study determines the structures of perforin-2 in solution and on membranes, revealing its conformational transition mechanism during pore formation.

bioRxiv · Jun 14, 2022 · PreprintBiophysics

Tales of Two α-Carboxysomes: the Structure and Assembly of Cargo Rubisco

T. Ni, Y. Sun, W. Seaton-Burn, M. M. Al-Hazeem, Y. Zhu, X. Yu, L.-N. Liu, p. zhang

This study uses cryo-electron tomography to reveal the 3D organization of Rubisco in two types of carboxysomes from different bacteria, showing distinct structural arrangements and responses to calcium treatment.

bioRxiv · Mar 15, 2022 · PreprintMicrobiology

Structural, functional and computational studies of membrane recognition by Plasmodium Perforin-Like Proteins 1 and 2.

S. Williams, X. Yu, T. Ni, R. Gilbert, P. Stansfeld

This study compares the membrane-binding properties of Plasmodium vivax PLP1 and PLP2 with Toxoplasma gondii PLP1 using structural and functional analyses.

bioRxiv · Dec 16, 2021Biophysics

QSAR Model Based Gradient Boosting Regression of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Inhibitors for Fructose-1,6-Bisphosphatase

Z. Zhao, J. Yang, B. LI, T. Sun, H. Si, T. Ni

This study develops a Gradient Boosting Regression model to predict the inhibitory activity of N-Arylsulfonyl-Indole-2-Carboxamide derivatives against Fructose-1,6-Bisphosphatase, achieving high correlation and statistical significance.

bioRxiv · Aug 10, 2021Biochemistry

Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system

F. Zhao, X. Lin, K. Cai, Y. Jiang, T. Ni, Y. Chen, J. Feng, S. Dang, C.-Z. Zhou, Q. Zeng

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

bioRxiv · Jul 20, 2021 · PreprintMicrobiology

Probing the biogenesis pathway and dynamics of thylakoid membranes

T. Huokko, T. Ni, G. Dykes, D. Simpson, P. Brownridge, F. Conradi, R. Beynon, P. Nixon, C. Mullineaux, P. Zhang, L.-N. Liu

The paper investigates thylakoid membrane biogenesis in cyanobacteria by modulating light intensity, revealing the spatial-temporal dynamics of protein complex insertion and membrane organization.

bioRxiv · May 5, 2021Plant Biology

SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

L. Mendonca, A. Howe, J. B. Gilchrist, D. Sun, M. Knight, L. C. Zanetti-Domingues, B. Bateman, A.-S. Krebs, L. Chen, J. Radecke, Y. Sheng, V. D. Li, T. Ni, I. Kounatidis, M. A. Koronfel, , P. Zhang

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

bioRxiv · Nov 5, 2020 · PreprintMicrobiology

Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex

L. Gui, K. Song, D. Tristchler, R. Bower, Y. Si, A. Dai, K. Augsperger, J. Sakizadeh, M. Grzemska, T. Ni, M. E. Porter, D. Nicastro

This study uses cryo-electron tomography to determine the structure of the N-DRC in Chlamydomonas flagella and identifies key subunit interactions and assembly requirements.

bioRxiv · Jun 27, 2019Cell Biology