Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer
Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw, Chris McCann, Nikita Lewis, Matilda Downs, Rebecca Wurelly, Ciara Cunningham, Aaron Philips, Niamh Doherty, Sarah Gallagher, William J. McDaid, Andrew J. Roe, Aisling Y. Coughlan, Brenton Cavanagh, , Emma M. Kerr
This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.
Nature Metabolism · Jul 23, 2026Peer-reviewedCancer Biology