Author

Matilda Downs

Queen's University Belfast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Connor N. BrowniD· 3 shared Emma M. KerriD· 3 shared A.R. Phillips· 2 shared Chris McCann· 2 shared Deborah Y. Moss· 2 shared Donna M. SmalliD· 2 shared Nikita LewisiD· 2 shared Sarah Maguire· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Connor N. BrownORCID

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Author profile →

3 papers

Recent·Most cited

FLIP is essential for oncogenic KRAS-driven lung cancer

Claudia Hamilton, Shaun Sharkey, Hajrah A. Khawaja, Matilda Downs, Christopher McLaughlin, Connor N. Brown, Declan F. Doherty, Jennifer Fox, Mihaela Pettigrew, Karl T. Butterworth, A.R. Phillips, Donna M. Small, Timothy Harrison, Catherine A. Higgins, Emma M. Kerr, Daniel B. Longley

This study identifies FLIP as a critical survival factor in KRAS-mutant lung cancers, revealing a KRAS-ERK-FLIP axis that protects against apoptosis and suggests FLIP as a therapeutic target.

bioRxiv · Aug 5, 2026 · PreprintCancer Biology

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw, Chris McCann, Nikita Lewis, Matilda Downs, Rebecca Wurelly, Ciara Cunningham, Aaron Philips, Niamh Doherty, Sarah Gallagher, William J. McDaid, Andrew J. Roe, Aisling Y. Coughlan, Brenton Cavanagh, , Emma M. Kerr

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

Nature Metabolism · Jul 23, 2026Peer-reviewedCancer Biology

Mutant KRAS dosage contributes to heterogeneity in lung cancer therapeutic response

Alice T. Browne, Chris McCann, William J. McDaid, Nikita Lewis, Sandhya Sridhar, Gary Joseph Doherty, Deborah Y. Moss, Matilda Downs, Stephen Marry, A.R. Phillips, Connor N. Brown, Alyson Speed, Gemma E. Logan, Gera L. Jellema, James R. Bradford, , Emma M. Kerr

This study shows that mutant KRAS dosage affects therapeutic response in lung cancer, with higher dosages linked to resistance to platinum therapy and sensitivity to pS6K inhibition.

bioRxiv · May 9, 2026 · PreprintCancer Biology