Author
Queen's University BelfastORCID 0009-0008-8914-1358Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Claudia Hamilton, Shaun Sharkey, Hajrah A. Khawaja…·Daniel B. Longley
This study identifies FLIP as a critical survival factor in KRAS-mutant lung cancers, revealing a KRAS-ERK-FLIP axis that protects against apoptosis and suggests FLIP as a therapeutic target.
Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw…·Emma M. Kerr
This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.
Alice T. Browne, Chris McCann, William J. McDaid…·Emma M. Kerr
This study shows that mutant KRAS dosage affects therapeutic response in lung cancer, with higher dosages linked to resistance to platinum therapy and sensitivity to pS6K inhibition.