A Topological Switch Enables Misfolding of the Cystic Fibrosis Transmembrane Conductance Regulator
Daniel Scholl, Maud Sigoillot, Marie Overtus, Rafael Colomer Martinez, Chloé Martens, Yiting Wang, Els Pardon, Toon Laeremans, Abel Garcia-Pino, Jan Steyaert, David Noel Sheppard, Jelle Hendrix, Cédric Govaerts
This study identifies a topological switch in CFTR's NBD1 domain that regulates channel function and contributes to misfolding in F508del-CFTR.
bioRxiv · Jul 9, 2020 · PreprintBiochemistry