Cédric Govaerts

This study uses HDX-MS to show that local conformational plasticity in MFS transporters enables ligand recognition and proton coupling, revealing dynamic adaptations beyond static structures.

This paper develops a cell-permeable nanobody to restore function of the misfolded F508del-CFTR protein in CF bronchial epithelial cells.

This study reports crystal structures of the QacA efflux pump in different conformational states, revealing structural dynamics and mechanisms of multidrug transport and extrusion.

This study uses a nanobody to stabilize mutant CFTR, revealing a novel active conformation and improving its function in cystic fibrosis.

This study uses smFRET to analyze conformational dynamics of LmrP, revealing antibiotic-dependent heterogeneity in its conformational landscape and interconversion kinetics.

This study identifies a topological switch in CFTR's NBD1 domain that regulates channel function and contributes to misfolding in F508del-CFTR.

The paper identifies a conserved vestibule binding site in pLGICs and shows nanobodies can act as allosteric modulators, expanding drug design possibilities.