Chloé Martens

This study uses HDX-MS to show that local conformational plasticity in MFS transporters enables ligand recognition and proton coupling, revealing dynamic adaptations beyond static structures.

This study reports crystal structures of the QacA efflux pump in different conformational states, revealing structural dynamics and mechanisms of multidrug transport and extrusion.

The paper shows that slow diffusion in biomolecular condensates limits phosphorylation kinetics, with phosphorylation rates strongly correlated to substrate diffusion coefficients.

This study identifies nanobodies that modulate Rel and RelA enzyme activity by trapping them in specific conformational states, inhibiting (p)ppGpp synthesis and affecting bacterial virulence.

This study uses smFRET to analyze conformational dynamics of LmrP, revealing antibiotic-dependent heterogeneity in its conformational landscape and interconversion kinetics.

This study shows that the bacterial immunity protein CapRelSJ46 can sense two distinct phage proteins using the same domain, highlighting its versatility in anti-phage defense.

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

This study identifies a topological switch in CFTR's NBD1 domain that regulates channel function and contributes to misfolding in F508del-CFTR.

Deuteros is a software tool for rapid analysis and visualization of differential HDX-MS data, designed to work with Waters DynamX.