Marie Overtus

This paper develops a cell-permeable nanobody to restore function of the misfolded F508del-CFTR protein in CF bronchial epithelial cells.

This study uses a nanobody to stabilize mutant CFTR, revealing a novel active conformation and improving its function in cystic fibrosis.

This study identifies a topological switch in CFTR's NBD1 domain that regulates channel function and contributes to misfolding in F508del-CFTR.