Jelle Hendrix

This paper develops a multimodal framework using spectral and lifetime phasor analysis to characterize microenvironmental changes in Tau condensates during maturation.

The paper evaluates FRET-based vinculin tension sensors to determine optimal design parameters for measuring molecular forces in cells.

This study uses ABEL-FRET to measure structural dynamics of A2A adenosine receptors across timescales, showing agonists shift receptor states and accelerate conformational exchange.

This study uses smFRET to analyze conformational dynamics of LmrP, revealing antibiotic-dependent heterogeneity in its conformational landscape and interconversion kinetics.

This study shows that polystyrene sulfonate (PSS) reduces toxicity of ALS-linked dipeptide repeat proteins in cellular and iPSC-derived motor neuron models.

The paper uses machine learning to cluster nanosized fluorescent extracellular vesicles, assessing their purity and inflammatory status, and identifies biomarkers for diagnostic profiling.

This study identifies a topological switch in CFTR's NBD1 domain that regulates channel function and contributes to misfolding in F508del-CFTR.

This study reveals a guanosine-switch mechanism that regulates the opposing activities of bifunctional Rel enzymes through allosteric changes.