The rhomboid-like pseudoprotease TMEM115 defines a two-factor mechanism for Rab6A effector recruitment
Boyan Zhang, Owain J. Bryant, Nadine Muschalik, Clémence Levet, Laura Charlier, Ángela Moncada-Pazos, Nina Jajcanin Jozic, Xin Shen, Fangfang Lu, Abhimanyu Gowda, Stefan Düsterhöft, Susan M. Lea, Sean Munro, Matthew Freeman
This study identifies TMEM115 as a two-factor component with Rab6A that recruits the golgin TMF1 to the Golgi apparatus, with implications for protein trafficking and disease.
bioRxiv · Sep 7, 2026 · PreprintCell Biology