Susan M. Lea

The paper identifies an expanded LPS translocon in Bacteroidota bacteria that mediates surface lipoprotein export, revealing structural and functional differences from the E. coli system.

This study identifies TMEM115 as a two-factor component with Rab6A that recruits the golgin TMF1 to the Golgi apparatus, with implications for protein trafficking and disease.

The paper identifies simplifying principles governing peptide binding by the promiscuous chicken class I molecule BF2*21:01, revealing patterns that enable broad peptide repertoire while maintaining stable binding.

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

The paper presents cryo-EM structures of the bacterial flagellar Export Apparatus, revealing a rotary gating mechanism coupling proton flow to export channel opening.

The paper reports the cryoEM structure of TraT, an outer membrane protein involved in plasmid exclusion, and suggests it functions by physical interference rather than specific protein interactions.

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

This study investigates the structural differences in mitotic-centrosome assembly between Drosophila and C. elegans, showing divergent mechanisms involving Cnn and SPD-5 proteins.

The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.

The paper presents structures of the Tat core complex in resting and substrate-bound states, revealing how substrate proteins interact with the complex through their signal peptides and proposing a model for early transport steps.

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

The paper identifies two distinct immunity protein families that neutralize a bacterial toxin from different compartments.

The paper identifies a shared mechanism between Bacteroidota gliding motility and T9SS protein transport involving disulfide-bonded outer membrane proteins.

This study reports the cryoEM structure of a BAM complex from Flavobacterium johnsoniae, revealing a novel structural paradigm for outer membrane protein biogenesis in Bacteroidota.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

The paper shows that the Delta C2 domain β1-2 loop is essential for phospholipid binding and robust Notch signaling in Drosophila.

This study reveals the structural control of type-3 secretion system assembly in Salmonella, showing how structural features guide the formation of a 24:16/15 basal body and regulate protein secretion.

This paper designs chimeric antigens for multivalent protein vaccines by combining immunogenic epitopes from integral membrane proteins with a molecular scaffold, showing efficacy in mice against meningococcal disease.

The paper determines the structure of the T3SS export gate core using cryo-EM, revealing a helical assembly with 5:4:1 stoichiometry and identifying it as a key component of the secretion channel.