Bhlhe40 Governs T Cell Effector Differentiation with Distinct Requirements in CD4 and CD8 T Cells for Anti-PD-1 and Anti-CTLA-4 Efficacy
Akata Saha, Tomoyuki Minowa, Alexander S. Shavkunov, Avery J. Salmon, Sunita Keshari, Suresh Satpati, Nicholas N. Jarjour, Abhinav K. Jain, Kunal Rai, Kristen E. Pauken, Kenneth H. Hu, Brian T. Edelson, Ken Chen, Matthew M. Gubin
This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.
bioRxiv · Oct 10, 2025 · PreprintImmunology