Kristen E. Pauken

IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus

This study identifies distinct transcriptional features in fibroblasts and myeloid cells of ICI-LP compared to LP, highlighting differences in IGF1, JAK-STAT, and interferon pathways.

Bhlhe40 Governs T Cell Effector Differentiation with Distinct Requirements in CD4 and CD8 T Cells for Anti-PD-1 and Anti-CTLA-4 Efficacy

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

Dietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade

This study shows that dietary methionine restriction enhances T cell metabolism and improves anti-PD1 checkpoint blockade efficacy in immunocompetent tumor models.

In vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity

This study shows that changing antibody administration route and fluorophore improves leukocyte labeling efficiency, sensitivity, and duration for tracking migration.