Abhishek Sharma

Glycoconjugates tune the viscoelastic signature of mammary tumor progression

This study shows that breast tumors are more viscoelastic than normal tissue, driven by glycoconjugates, and that increased viscoelasticity promotes malignant behavior in epithelial cells.

Determining organ size through growth rate dependent negative feedback without sensing size.

This paper proposes a model for organ size determination in Drosophila imaginal discs where growth rate-dependent negative feedback, not size sensing, regulates size restoration during growth.

Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates Nanotherapeutics

This paper designs a new class of antibody-drug conjugates by leveraging drug hydrophobicity to create self-assembling nanotherapeutics with improved therapeutic properties.

Matrix stiffness and stress relaxation regulate osteogenesis through histone demethylases KDM4B and KDM6B

This study shows that matrix stiffness and stress relaxation influence osteogenesis by regulating histone demethylases KDM4B and KDM6B through mechanotransduction signaling.

Nutrient/TOR signaling controls Mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

This study shows that TOR signaling regulates TFAM protein levels in Drosophila larvae, linking nutrient availability to mitochondrial function and organismal growth.