Lysosome positioning affects NLRP3 inflammasome activation
Billie J. Matchett, Jack Green, Paula I. Seoane, Abigail Owen, Tomasz Drobkiewicz, Hayley J. Bennett, Antony D. Adamson, Gloria López‐Castejón, Christopher Hoyle, Martin Lowe, David Brough
This study investigates how lysosome positioning affects NLRP3 inflammasome activation in HeLa and macrophage cells, finding that peripheral lysosome positioning enhances inflammasome activation.
bioRxiv · Mar 21, 2025 · PreprintImmunology