Martin Lowe

In vivo cellular localisation and nanoscale organisation of NLRP3 inflammasomes

This study uses reporter mice to visualise NLRP3 inflammasomes in vivo, revealing their localisation, organisation, and cellular sources.

Morphological determinants of glycosylation efficiency in Golgi cisternae

The paper develops a mathematical model to quantify how Golgi cisterna morphology affects glycosylation efficiency, identifying optimal and maximal thicknesses for successful polymer production.

Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship

This study shows that GMAP210 and Golgin-160 have distinct roles in maintaining Golgi structure, both necessary for efficient ECM secretion and modification.

Lysosome positioning affects NLRP3 inflammasome activation

This study investigates how lysosome positioning affects NLRP3 inflammasome activation in HeLa and macrophage cells, finding that peripheral lysosome positioning enhances inflammasome activation.

Critical role of PCYT2 in muscle health and aging

This study identifies PCYT2 as critical for muscle health and aging, showing its deficiency causes muscle weakness and aging, and demonstrates therapeutic potential through AAV-based delivery.