Cell-Type-Specific Epigenetic Priming of Gene Expression in Nucleus Accumbens by Cocaine
Philipp Mews, Yentl Y. van der Zee, Hope G. Kronman, Ashik Gurung, Aarthi Ramakrishnan, Caleb J. Browne, Rita Futamura, Molly Estill, Meagan Ryan, Abner A. Reyes, Benjamin A Garcia, Simone Sidoli, Li Shen, Eric J. Nestler
This study identifies a novel epigenetic mechanism by which chronic cocaine exposure alters gene expression in nucleus accumbens neurons through H2A.Z depletion and chromatin changes.
Science Advances · Oct 4, 2024Peer-reviewedMolecular Biology