Philipp Mews

This study shows bile acids modulate cholinergic interneuron activity and dopamine release in the nucleus accumbens via TGR5 activation and concentration-dependent effects.

This study identifies a novel epigenetic mechanism by which chronic cocaine exposure alters gene expression in nucleus accumbens neurons through H2A.Z depletion and chromatin changes.

The paper uses single-nucleus RNA sequencing to identify transcriptional changes in D1 and D2 neurons of the nucleus accumbens following cocaine exposure and withdrawal.

The paper compares gene expression in the nucleus accumbens during cocaine withdrawal and extinction in rats, identifying distinct transcriptional patterns associated with different behavioral outcomes.

The paper examines transcriptomic changes in D1 and D2 medium spiny neurons of the nucleus accumbens after cocaine and morphine exposure, revealing shared and divergent regulatory patterns.

This study identifies RXR as a key regulator of drug reward sensitivity in the nucleus accumbens through transcriptional control of neuronal excitability in mice.

This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.