Rita Futamura

The paper identifies synaptic bioenergetic remodeling in the mPFC after heroin abstinence, but not cocaine, and links it to relapse vulnerability.

The paper identifies a role for prefrontal cortex astrocytes in stress resilience using mouse models and RNA-sequencing, showing distinct transcriptional responses between resilient and susceptible mice.

The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.

This study identifies a novel epigenetic mechanism by which chronic cocaine exposure alters gene expression in nucleus accumbens neurons through H2A.Z depletion and chromatin changes.

The paper identifies dopaminylated proteins in the brain, including γCaMKII, and shows its role in synaptic-to-nuclear signaling and memory formation.

This study shows that E2F3a overexpression in D1-MSNs increases cocaine reward in both male and female mice, while knockdown has opposite effects, with no impact in D2-MSNs.

The paper compares gene expression in the nucleus accumbens during cocaine withdrawal and extinction in rats, identifying distinct transcriptional patterns associated with different behavioral outcomes.

The paper examines transcriptomic changes in D1 and D2 medium spiny neurons of the nucleus accumbens after cocaine and morphine exposure, revealing shared and divergent regulatory patterns.

This study investigates how chronic morphine exposure and withdrawal alter tRNA cytosine methylation in the medial prefrontal cortex, linking these changes to reward-seeking behavior and opioid use disorder.

This study identifies transcriptional changes in the brain reward circuit across heroin exposure and seeking behaviors in mice, revealing molecular mechanisms and potential therapeutic targets for opioid use disorder.

This study identifies RXR as a key regulator of drug reward sensitivity in the nucleus accumbens through transcriptional control of neuronal excitability in mice.

The paper identifies FEDORA, a lncRNA with sex- and cell-type-specific effects on depression in females.

This study maps ΔFOSB binding sites in nucleus accumbens neurons after chronic cocaine exposure using CUT&RUN, revealing enhancer-like regions and interactions with BRG1 and other transcription factors.