Caleb J. Browne

The paper identifies synaptic bioenergetic remodeling in the mPFC after heroin abstinence, but not cocaine, and links it to relapse vulnerability.

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

This study identifies transcriptional differences in mice with antidepressant resistance using RNA sequencing of brain regions after stress and drug treatment.

The paper identifies a shared transcriptional network in the nucleus accumbens that supports stress resilience in both sexes and shows causal effects of hub genes.

The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.

This study identifies a novel epigenetic mechanism by which chronic cocaine exposure alters gene expression in nucleus accumbens neurons through H2A.Z depletion and chromatin changes.

This study shows that E2F3a overexpression in D1-MSNs increases cocaine reward in both male and female mice, while knockdown has opposite effects, with no impact in D2-MSNs.

This study identifies H3K27me1 as a chromatin scar that mediates lifelong stress susceptibility through its role in altering gene expression in the nucleus accumbens.

This study identifies Rheb as a molecular substrate in the nucleus accumbens that enables drugs of abuse to hijack reward circuits and suppress natural reward responses.

The paper identifies sex-specific regulation of stress susceptibility by the astrocytic gene Htra1 in mice and humans, showing differential effects on neuronal signaling and ECM integrity.

The paper compares gene expression in the nucleus accumbens during cocaine withdrawal and extinction in rats, identifying distinct transcriptional patterns associated with different behavioral outcomes.

The paper investigates genetic and sex differences in stress and morphine responses across mouse strains and their progeny, finding genetic influences on stress vulnerability and morphine sensitivity.

The paper examines transcriptomic changes in D1 and D2 medium spiny neurons of the nucleus accumbens after cocaine and morphine exposure, revealing shared and divergent regulatory patterns.

This study investigates how chronic morphine exposure and withdrawal alter tRNA cytosine methylation in the medial prefrontal cortex, linking these changes to reward-seeking behavior and opioid use disorder.

This study identifies transcriptional changes in the brain reward circuit across heroin exposure and seeking behaviors in mice, revealing molecular mechanisms and potential therapeutic targets for opioid use disorder.

This study identifies RXR as a key regulator of drug reward sensitivity in the nucleus accumbens through transcriptional control of neuronal excitability in mice.

The paper identifies FEDORA, a lncRNA with sex- and cell-type-specific effects on depression in females.

This study maps ΔFOSB binding sites in nucleus accumbens neurons after chronic cocaine exposure using CUT&RUN, revealing enhancer-like regions and interactions with BRG1 and other transcription factors.

The paper shows that adolescent social isolation causes sex-specific changes in the medial amygdala's transcriptome and behavior, with Crym playing a key role in these effects.