Esophageal epithelial Ikkβ deletion promotes eosinophilic esophagitis in experimental allergy mouse model
Margarette H. Clevenger, Cenfu Wei, Adam L. Karami, Lia Elyse Tsikretsis, Dustin A. Carlson, John Erik Pandolfino, Nirmala Prabu Gonsalves, Deborah R. Winter, Kelly A. Whelan, Marie‐Pier Tétreault
This study shows that deleting Ikkβ in esophageal epithelial cells worsens eosinophilic esophagitis in a mouse model, highlighting the importance of IKKβ/NFκB signaling in preventing allergic inflammation.
Journal of Allergy and Clinical Immunology · Jul 10, 2024Peer-reviewedImmunology