Kathryn E. Hamilton

The Human Gut Cell Atlas v1.0: A Unified, Community-Built Reference of Cellular Diversity Across the Gut

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn's disease

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

Gastric epithelium from BRCA1 and BRCA2 carriers harbors increased double-stranded DNA damage and augmented growth.

This study finds BRCA1 and BRCA2 carriers have increased DNA damage and growth in gastric epithelium and organoids, suggesting haploinsufficiency contributes to early gastric cancer development.

TNFSF13 insufficiency disrupts human colonic epithelial cell-mediated B cell differentiation

This study investigates the role of TNFSF13 in colonic epithelial cell-B cell interactions and finds that TNFSF13 insufficiency disrupts B cell differentiation and epithelial growth.

Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium and age-associated mitochondrial dysfunction

This study uses single-cell RNA sequencing to identify cellular diversity and age-related mitochondrial dysfunction in murine esophageal epithelium.

Posttranscriptional regulation of intestinal epithelial cell repair by RNA binding protein IMP1

This study shows IMP1 regulates intestinal epithelial repair after irradiation and colitis by modulating autophagy through direct binding to autophagy transcripts.