Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function
Sean R. McCutcheon, Adam M. Swartz, Michael C. Brown, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas L. Humayun, James M. Isaacs, Timothy E. Reddy, Smita K. Nair, Scott J. Antonia, Charles A. Gersbach
The paper uses CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function, finding BATF3 as a key gene that enhances memory T cell features and improves CAR T cell therapy outcomes.
bioRxiv · May 1, 2023 · PreprintGenomics