Christian D. McRoberts Amador

The paper identifies transcription factor collaborations that shape CD8+ T cell states and demonstrates how engineering these interactions can influence cell fate for therapeutic applications.

This study identifies RELB as a key regulator that enhances TIL expansion and function, improving adoptive cell therapy for solid tumors.

This paper introduces a CRISPRi system using dHyperLbCas12a for highly multiplexed epigenome editing and demonstrates its application in proliferation and CRE analysis screens.

The paper uses CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function, finding BATF3 as a key gene that enhances memory T cell features and improves CAR T cell therapy outcomes.