GenomicsbioRxivPreprint
Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function
Sean R. McCutcheon, Adam M. Swartz, Michael C. Brown…·Charles A. Gersbach
The paper uses CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function, finding BATF3 as a key gene that enhances memory T cell features and improves CAR T cell therapy outcomes.
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