Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma
Carole A. Daly, Adam Wright, Raimond Heukers, Chloe M. McKee, Rebecca C. Coll, Emma Evergren, Martine J. Smit, Alex Rojas Bie Thomsen, Bianca Plouffe
The paper shows that US28's Gq/11 signaling from the plasma membrane, not endosomes, primarily drives gene expression related to glioblastoma proliferation and inflammation.
bioRxiv · Jun 12, 2025 · PreprintCell Biology