Chloe M. McKee

This study shows high temperatures inhibit NLRP3 inflammasome activation, identifying NLRP3 as a thermosensor and revealing a temperature-sensitive conformational change in its C-terminal domain.

This study generates and benchmarks iPSC-derived macrophages (iMacs) as a model for human inflammasome signaling, showing they respond to multiple inflammasome stimuli and activate unique pathways.

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

The paper shows that US28's Gq/11 signaling from the plasma membrane, not endosomes, primarily drives gene expression related to glioblastoma proliferation and inflammation.