A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Elizabeth Godschall, Taha Buğra Güngül, Isabelle R. Sajonia, Aleyna K. Buyukaksakal, Orien Dong-Ang Li, Sophia Ogilvie, Austin B. Keeler, Guilian Tian, Omar Koita, Yu Shi, Tyler C J Deutsch, Maisie Crook, YuChen Zhang, Nicholas J. Conley, Addison N. Webster, , Ali D. Güler
This paper shows small-molecule GLP1RAs modulate reward processing via a specific neural circuit in the central amygdala, affecting dopamine release and hedonic feeding.
bioRxiv · Dec 12, 2024 · PreprintNeuroscience