Andrew Lutas

This study identifies POA H1 receptor-expressing neurons as key regulators of thermoregulatory behaviors, including body temperature rhythms and nest building.

This paper develops a micro-endoscope probe to simultaneously track multiple neuromodulators in real time using fluorescent sensors, demonstrating its use in brain slices and awake mice.

This study identifies that semaglutide induces weight loss via cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons through both Gs- and Gq-signaling pathways.

This study investigates the role of cAMP-dependent signaling pathways in cocaine-induced immediate-early gene expression in D1 medium-spiny neurons of the nucleus accumbens, identifying distinct pathways for Egr-1 and c-Fos induction.

This study identifies an amygdalopontine pathway that drives ingestive behaviors independent of satiety signals, promoting goal-directed motor programs of ingestion.

This paper identifies distinct roles of dopamine D3 and D1 receptors in regulating motivation and reinforcement in the nucleus accumbens, showing compartmentalized signaling within the same cell type.

The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

The paper shows that transient cAMP production in brainstem parabrachial neurons suppresses feeding for minutes, matching the duration of cAMP and calcium activity elevations.

The paper shows that cortical reactivations predict future sensory responses and representational drift in mice.

This study shows chronic stress can lead anxious female mice to prefer a starvation-like state induced by AgRP neuron activation.

The paper investigates dopamine-dependent cAMP dynamics in basal amygdala glutamatergic neurons during salient events, showing that cAMP responses decay more slowly than dopamine release and exhibit depression with repeated stimulation.

The paper investigates how midbrain dopaminergic input to the basal amygdala gates responses to salient cues during learning in mice.