Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety
Addison N. Webster, Jordan J. Becker, Chia Li, Dana C. Schwalbe, Damien Kerspern, Eva O. Karolczak, Catherine B. Bundon, Roberta Onoharigho, Maisie E. Crook, Maira Jalil, Elizabeth Godschall, Emily G. Dame, Adam Dawer, Dylan M. Rausch, Tune H. Pers, , John N. Campbell
The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.
Nature Metabolism · Dec 3, 2024Peer-reviewedNeuroscience